Definitive sanctification, as defined by John Frame, is "a once-for-all event, simultaneous with effectual calling and regeneration, that transfers us from the sphere of sin to the sphere of God’s holiness, from the kingdom of Satan to the kingdom of God." Definitive sanctification marks us out (or separates us) as God’s chosen people – His treasured and covenantal possession (Acts 20:32; Rom. 1:7; 1 Cor. 1:2; 6:11). So too, definitive sanctification redeems (or frees) us from the dominion (or slavery) of sin by uniting us to Christ, particularly in His death, resurrection and ascension. Sanctification, in this sense, refers to a decisive and radical break with the power and pleasures of sin.
Progressive sanctification, as defined by Wayne Grudem, is "a progressive work of God and man that makes us more and more free from sin and like Christ in our actual lives." According to John Frame, "We can think of sanctification as the outworking of the new life given in regeneration." It involves the gradual, incremental and (S)piritual work of both putting to death the remains of "indwelling sin" as well as putting on the likeness of Christ.
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